Polynucleotides: A Complete Guide

Polynucleotides have moved from a niche interest to a mainstream topic of conversation among aesthetics practitioners across the UK. This guide brings together the key points practitioners need to understand before considering polynucleotides as part of their treatment offering, from the underlying science to practical considerations around patient selection and sourcing.

Understanding Polynucleotides

Polynucleotides are naturally occurring biopolymers made up of chains of nucleotides. In an aesthetic context, purified polynucleotide fragments are formulated into injectable products intended to be introduced into the skin, where they are thought to interact with the skin’s own cellular environment. The proposed mechanism of action relates to supporting the skin’s natural repair and regeneration processes, which is why polynucleotides are often grouped within the broader “regenerative aesthetics” category alongside treatments such as skin boosters.

Unlike dermal fillers, polynucleotides are not designed to add volume. Instead, the intended focus is on the underlying quality of the skin — its hydration, firmness and overall condition — which is why they are often discussed as a complementary treatment rather than a replacement for volumising procedures.

Potential Applications in Practice

Polynucleotide treatments are most commonly discussed in relation to the face, including areas such as the under-eye region, but formulations and licensed uses vary by product and manufacturer. Some practitioners also explore their use in areas such as the neck, décolletage and scalp, again depending on the specific product’s approved indications and instructions for use.

As this is a developing treatment area, practitioners should always refer to the specific product’s instructions for use (IFU) and manufacturer guidance rather than assuming that findings for one product or application extend to another. Formulations, concentrations and recommended protocols differ between manufacturers.

Patient Consultation and Suitability

A thorough consultation remains the foundation of safe, effective polynucleotide treatment. Key elements typically include:

• A full medical history, including any relevant allergies, medications or existing skin conditions.
• A clear discussion of the patient’s aesthetic goals and an honest assessment of what may realistically be achieved.
• Screening for contraindications, which may include pregnancy and breastfeeding, active skin infections, and certain autoimmune or connective tissue conditions, in line with the specific product’s IFU.
• A transparent conversation about the likely treatment course, expected timelines, and the possibility of temporary side effects such as swelling, redness or bruising.

Informed consent should always make clear that, as with any injectable treatment, results cannot be guaranteed and will vary from patient to patient depending on individual factors such as skin condition, age and lifestyle.

Combining Polynucleotides With Other Treatments

Many practitioners consider how polynucleotides might fit alongside other treatments already offered in their clinic, such as skin boosters, microneedling or dermal fillers. While some practitioners do combine modalities as part of a broader skin quality programme, any decision to do so should be based on individual patient assessment, product-specific guidance, and appropriate spacing between treatments rather than a general assumption that combining treatments is always beneficial.

Practitioners should also stay mindful that the aesthetics landscape is evolving quickly, and new products, formulations and delivery methods continue to emerge. Keeping up to date with manufacturer updates, professional body guidance and continuing education is an important part of using any regenerative treatment responsibly.

Sourcing Polynucleotide Products Responsibly

Given the rapid growth in this category, practitioners should be particularly diligent when sourcing polynucleotide products. Considerations include confirming appropriate regulatory approval for the UK market, reviewing available clinical data and manufacturer documentation, and choosing suppliers who verify practitioner qualifications before supply — a standard safeguard that protects both patients and practitioners.

Working with an established, UK-based supplier also helps ensure correct storage and handling throughout the supply chain, along with access to up-to-date product training and clinical support materials.

Final Thoughts

Polynucleotides offer an interesting addition to the aesthetics toolkit, with a growing but still developing evidence base. Practitioners who take the time to understand the science, select patients carefully, and communicate honestly about expected outcomes are best placed to use these treatments responsibly.

Fox Pharmacy stocks a range of polynucleotide products for qualified UK aesthetics professionals, along with supporting product information. Browse our range or contact our team to find out more about the options available and any associated training.