Aftercare to Reduce Polynucleotide Injection Side Effects

Polynucleotide treatments have grown in popularity across UK aesthetic clinics thanks to their regenerative, skin-conditioning properties. As with any injectable procedure, patients may experience some temporary side effects such as mild swelling, redness, tenderness or small bumps at the injection sites. While these effects are generally short-lived and expected as part of the skin’s normal response, thoughtful aftercare advice can help support a smoother recovery and improve patient comfort and confidence in the days following treatment. This article outlines aftercare guidance that practitioners may wish to share with patients after a polynucleotide session, alongside a reminder that individual responses vary and treatment should always follow the manufacturer’s IFU and your own clinical training.

Immediately After Treatment

In the hours following treatment, patients are often advised to avoid touching or applying pressure to the treated area unless instructed to do so by their practitioner. A cool compress, applied gently and briefly, may help some patients manage temporary swelling or discomfort, though this should be discussed on an individual basis. Patients should also be advised to avoid makeup application over the treated area for a short period, and to keep the skin clean using a gentle, non-irritating cleanser.

The First 24 to 48 Hours

Many clinics recommend that patients avoid strenuous exercise, saunas, steam rooms and hot showers or baths for a day or two following treatment, as increased blood flow and heat may contribute to swelling. Alcohol consumption is often discouraged during this window, and patients may be advised to sleep with their head slightly elevated if swelling is a concern. Sun exposure and sunbeds are generally best avoided, with a broad-spectrum SPF recommended once the skin has settled, as protecting the skin barrier supports the overall treatment outcome.

Supporting the Skin’s Response

Because polynucleotides are designed to support the skin’s own repair processes, gentle skincare in the days following treatment can help create favourable conditions for recovery. Patients are often advised to avoid active ingredients such as retinoids or exfoliating acids for a short period, and to prioritise hydrating, fragrance-free products instead. Staying well hydrated and maintaining a balanced diet may also be discussed as general supportive measures, though clinical studies suggest that individual healing responses can vary considerably.

When to Contact the Clinic

Patients should always be given clear guidance on what to expect and when they should get back in touch. Mild bruising, small bumps or transient redness are commonly reported and usually resolve without intervention. However, patients should be encouraged to contact the clinic promptly if they experience signs that concern them, such as unusual or worsening symptoms, so that a practitioner can assess and advise appropriately. Having a documented aftercare leaflet and a clear escalation pathway is good practice for any clinic offering these treatments.

Fox Pharmacy supplies a range of polynucleotide products for qualified aesthetic professionals, alongside access to training resources to support safe and informed practice. Get in touch with our team or browse our polynucleotide range to find out more.